The authors of this famous paper thought they have disproved the Central Dogma. Not quite so. The study triggered the discovery of extremely interesting mechanisms of stress-induced mutagenesis but no "unicorn in the garden".
Somehow I suspect that the As story will evolve in the same direction. Although it would be tremendously exciting to be wrong with this prediction.
Chemists believe that the simple modeling of As-substituted DNA is quite enough to disprove the whole thing. Unless biologists think the DNA-related machinery can change accordingly in a course of 3-week evolution.
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To me, this reminds of the old story of induced mutations:
http://www.ncbi.nlm.nih.gov/pubmed/3045565
The authors of this famous paper thought they have disproved the Central Dogma. Not quite so. The study triggered the discovery of extremely interesting mechanisms of stress-induced mutagenesis but no "unicorn in the garden".
Somehow I suspect that the As story will evolve in the same direction. Although it would be tremendously exciting to be wrong with this prediction.
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Erratum